Transgenic overexpression of Tcfap2c/AP-2gamma results in liver failure and intestinal dysplasia.
BackgroundThe transcription factor Tcfap2c has been demonstrated to be essential for various processes during mammalian development.It has been found to be upregulated in various undifferentiated tumors and is implicated with poor prognosis.Tcfap2c is reported to impinge on cellular proliferation, differentiation and apoptosis.However, the physiolo